CriSP-HS

Title: Cold Stored Platelet Early Intervention in Hemorrhagic Shock (CriSP-HS) Trial

Summary: A multi-center blood transfusion clinical trial enrolling trauma patients in hemorrhagic shock requiring operative management. Patients enrolled in this trial are randomized to either standard of care (SOC) treatment or Cold Stored Platelet (CSP) intervention arm to receive a unit of CSP and additional blood products per SOC treatment.

ACTIV-4a

Title: A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults with COVID-19  (ACTIV-4a)

Summary: This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional treatment strategies for prevention of adverse outcomes in COVID-19 positive inpatients. 

PAIN

Title: Prehospital Analgesia INtervention trial (PAIN)

Summary: The PAIN trial is a 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial comparing fentanyl versus sub-dissociative ketamine for mortality outcome differences, safety, and analgesia in trauma patients with compensated shock.

CASA-RELAX

Title: Complex and Simple Appendicitis: Restrictive or Liberal post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)

Summary: This is an interventional and observational study for patients undergoing an appendectomy. The clinical trial aims to demonstrate the safety, efficacy, and feasibility of short course post-operative antibiotic treatment for simple and complicated appendicitis.

CAVALIER

Title: CAlcium and VAsopressin following Injury Early Resuscitation trial (CAVALIER) 

Summary: A double-blinded, multi-center, prehospital and early in-hospital randomized trial. The primary aim of this clinical trial is to determine whether prehospital calcium, early in-hospital vasopressin, or both as compared to placebo results in lower 30-day mortality in patients at risk of hemorrhagic shock.

CLOTT

Title: The Consortium of Leaders in the Study of Traumatic Thromboembolism (CLOTT) study group 

Summary: This is a prospective, multi-center study to describe the incidence of and the timing of the development of fibrinolytic shutdown in critically injured patients, identify the risk factors for the development of fibrinolytic shutdown after injury, and to investigate the association between fibrinolytic shutdown and the development of DVT and/or PE.