PAIN

Title: Prehospital Analgesia INtervention trial (PAIN)

Summary: The PAIN trial is a 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial comparing fentanyl versus sub-dissociative ketamine for mortality outcome differences, safety, and analgesia in trauma patients with compensated shock.

CASA-RELAX

Title: Complex and Simple Appendicitis: Restrictive or Liberal post-operative Antibiotic eXposure (CASA RELAX) Using Desirability of Outcome Ranking (DOOR) and Response Adjusted for Duration of Antibiotic Risk (RADAR)

Summary: This is an interventional and observational study for patients undergoing an appendectomy. The clinical trial aims to demonstrate the safety, efficacy, and feasibility of short course post-operative antibiotic treatment for simple and complicated appendicitis.

CAVALIER

Title: CAlcium and VAsopressin following Injury Early Resuscitation trial (CAVALIER) 

Summary: A double-blinded, multi-center, prehospital and early in-hospital randomized trial. The primary aim of this clinical trial is to determine whether prehospital calcium, early in-hospital vasopressin, or both as compared to placebo results in lower 30-day mortality in patients at risk of hemorrhagic shock.